(pdf reprints available upon request:hirase@brain.riken.jp).. For a more complete publication list of Dr. Hirase, click here.

Lab Publications

(+ denotes equally contributing author)

  • Monai H, Wang X, Yahagi K, Lou N, Mestre H, Xu Q, Abe Y, Yasui M, Iwai Y, Nedergaard M, Hirase H.
    Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke
    Proc Natl Acad Sci U S A. (2019) in press. DOI: 10.1073/pnas.1817347116

  • Hirase H, Akther S, Wang X, Oe Y.
    Glycogen distribution in mouse hippocampus.
    J Neurosci Res (2019, in press). DOI: 10.1002/jnr.24386

  • Monai H, Hirase H.
    Astrocytes as a target of transcranial direct current stimulation (tDCS) to treat depression.
    Neuroscience Research. (2018) 126:15-21. DOI: 10.1016/j.neures.2017.08.012

  • Tanaka M+, Wang X+, Mikoshiba K, Hirase H, Shinohara Y.
    Rearing-environment-dependent hippocampal local field potential differences in wildtype and inositol trisphosphate receptor type 2 knockout mice.
    J Physiol. (2017) 595:6557-6568. DOI: 10.1113/JP274573
  • 2016
  • Monai H, Hirase H.
    Astrocytic calcium activation in a mouse model of tDCS – extended discussion.
    Neurogenesis. (2016) e1240055. DOI: 10.1080/23262133.2016.1240055
  • Oe Y, Baba O, Ashida H, Nakamura KC, Hirase H.
    Glycogen distribution in the microwave-fixed mouse brain reveals heterogeneous astrocytic patterns.
    Glia. (2016) 64:1532-1545. DOI: 10.1002/glia.23020
  • Monai H, Ohkura M, Tanaka M, Oe Y, Konno A, Hirai H, Mikoshiba K, Itohara S, Nakai J, Iwai Y, Hirase H.
    Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain.
    Nat Commun. (2016) 7:11100. DOI: 10.1038/ncomms11100
  • Nuriya M, Hirase H.
    Involvement of astrocytes in neurovascular communication.
    Progress in Brain Research. (2016) 225:41-62. DOI: 10.1016/bs.pbr.2016.02.001
  • 2015
  • Nagai T, Takata N, Shinohara Y, Hirase H.
    Adaptive changes of extracellular amino acid concentrations in mouse dorsal striatum by 4-AP-induced cortical seizures.
    Neuroscience. (2015) 295:229-236. DOI: 10.1016/j.neuroscience.2015.03.043
  • 2014
  • Hirase H, Shinohara Y.
    Transformation of cortical and hippocampal neural circuit by environmental enrichment.
    Neuroscience. (2014) 280:282-298. DOI: 10.1016/j.neuroscience.2014.09.031
  • Hirase H, Iwai Y, Takata N, Shinohara Y, Mishima T.
    Volume transmission signalling via astrocytes.
    Philos Trans R Soc Lond B Biol Sci. (2014) 369:20130604. DOI: 10.1098/rstb.2013.0604
  • Takata N, Shinohara Y, Ohkura M, Mishima T, Nakai J, Hirase H.
    Imaging of astrocytic activity in living rodents.
    Neuromethods. (2014) 85:191-207. DOI: 10.1007/978-1-62703-785-3_12
    (book chapter: Helmchen and Weber (eds.) Optical Imaging of Neocortical Dynamics, Humana Press, Springer Science+Business Media, New York)
  • 2013
  • Takata N+, Nagai T+, Ozawa K+, Oe Y, Mikoshiba K, Hirase H.
    Cerebral blood flow modulation by basal forebrain or whisker stimulation can occur independently of large cytosolic Ca2+ signaling in astrocytes.
    PLoS One. (2013) 8(6): e66525. DOI: 10.1371/journal.pone.0066525
  • Shinohara Y, Hosoya A, Hirase H.
    Experience enhances gamma oscillations and interhemispheric asymmetry in the hippocampus.
    Nat Commun. (2013) 4:1652. DOI: 10.1038/ncomms2658
  • 2012
  • Shinohara Y, Hosoya A, Yahagi K, Ferecsko AS, Yaguchi K, Sik A, Itakura M, Takahashi M, Hirase H.
    Hippocampal CA3 and CA2 have distinct bilateral innervation patterns to CA1 in rodents.
    Eur J Neurosci. (2012) 35(5):702-10. DOI: 10.1111/j.1460-9568.2012.07993.x
  • 2011
  • Takata N+, Mishima T+, Hisatsune C, Nagai T, Ebisui E, Mikoshiba K, Hirase H.
    Astrocyte calcium signaling transforms cholinergic modulation to cortical plasticity in vivo.
    J. Neurosci. (2011) 31(49):18155-65. (correction) DOI: 10.1523/JNEUROSCI.5289-11.2011
  • Shinohara Y, Yahagi K, Kawano M, Nishiyori H, Kawazu C, Suzuki N, Manabe R, Hirase H.
    miRNA profiling of bilateral rat hippocampal CA3 by deep sequencing.
    Biochem Biophys Res Commun. (2011) 409(2):293-8. DOI: 10.1016/j.bbrc.2011.05.004

    The miRNA sequencing results (both raw sequence reads and analyses) are archived in the DDJB Sequence Read Archive (DRA) database. [accession number DRA000379]
  • Iwai Y, Honda S, Ozeki H, Hashimoto M, Hirase H.
    A simple head-mountable LED device for chronic stimulation of optogenetic molecules in freely moving mice.
    Neurosci Res. (2011) 70(1):124-7. DOI: 10.1016/j.neures.2011.01.007
  • 2010
  • Mishima T, Hirase H.
    In vivo intracellular recording suggests that gray matter astrocytes in mature cerebral cortex and hippocampus are electrophysiologically homogeneous.
    J. Neurosci. (2010) 30(8):3093-100. DOI: 10.1523/JNEUROSCI.5065-09.2010
  • 2009
  • Sakatani S, Yamada K, Homma C, Munesue S, Yamamoto Y, Yamamoto H, Hirase H.
    Deletion of RAGE causes hyperactivity and increased sensitivity to auditory stimuli in mice.
    PLoS One. (2009) 4(12):e8309. DOI: 10.1371/journal.pone.0008309
  • Shinohara Y, Hirase H.
    Size and receptor density of glutamatergic synapses: a viewpoint from left-right asymmetry of CA3-CA1 connections.
    Front. Neuroanat. (2009) 3:10. DOI: 10.3389/neuro.05.010.2009
  • 2008
  • Sakatani S, Seto-Ohshima A, Shinohara Y, Yamamoto Y, Yamamoto H, Itohara S, Hirase H.
    Neural activity dependent release of S100B from astrocytes enhances kainate-induced gamma oscillations in vivo.
    J. Neurosci. (2008) 28(43):10928-36. DOI: 10.1523/JNEUROSCI.3693-08.2008
  • Takata N, Hirase H.
    Cortical layer 1 and layer 2/3 astrocytes exhibit distinct calcium dynamics in vivo.
    PLoS One. (2008) 3(6):e2525. DOI: 10.1371/journal.pone.0002525
  • 2007
  • Mishima T, Sakatani S, Hirase H.
    Intracellular labeling of single cortical astrocytes in vivo.
    J Neurosci Methods. (2007) 166(1):32-40. DOI: 10.1016/j.jneumeth.2007.06.021
  • Sakatani S, Seto-Ohshima A, Itohara S, Hirase H.
    Impact of S100B on local field potential patterns in anesthetized and kainic acid induced seizure conditions in vivo.
    Eur J Neurosci. (2007) 25(4):1144-54. DOI: 10.1111/j.1460-9568.2007.05337.x
  • 2006
  • Gulyas AI, Buzsaki G, Freund TF, Hirase H.
    Populations of hippocampal inhibitory neurons express different levels of cytochrome c.
    Eur J Neurosci. (2006) 23(10):2581-94. DOI: 10.1111/j.1460-9568.2006.04814.x
  • 2005
  • Hirase H.
    A multi-photon window onto neuronal-glial-vascular communication.
    Trends Neurosci. (2005) 28(5):217-9. DOI: 10.1016/j.tins.2005.03.002
  • Publications through collaboration

  • Wu CH, Hung CY, Hirase H, Tain YL, Lee WC, Chan JYH, Fu, MH, Chen LW, Liu WC, Liang CK, Ho YH, Kung YC, L S, Wu KLH.
    Pioglitazone reverses the fructose-programmed astrocytic glycolysis and oxidative phosphorylation.
    American Journal of Physiology Endocrinology and Metabolism (2019) 316(4):E622-E634. DOI: 10.1152/ajpendo.00408.2018

  • Mestre H, Hablitz LM, Xavier ALB, Feng W, Zou W, Pu T, Monai H, Murlidharan G, Rivera RMC, Simon MJ, Pike MM, Plá V, Du T, Kress BT, Wang X, Plog BA, Thrane AS, Lundgaard I, Abe Y, Yasui M, Thomas JH, Xiao M, Hirase H, Asokan A, Iliff JJ, Nedergaard M.
    Aquaporin-4-dependent glymphatic solute transport in the rodent brain.
    eLife (2018) 7:e40070. DOI: 10.7554/eLife.40070

  • Ue Y, Monai H, Higuchi K, Nishiwaki D, Tajima T, Okazaki K, Hama H, Hirase H, Miyawaki A.
    A spherical aberration-free microscopy system for live brain imaging.
    Biochem Biophys Res Commun (2018) 500:236-241. DOI: 10.1016/j.bbrc.2018.04.049

  • Harada K, Ito M, Wang X, Tanaka M, Wongso D, Konno A, Hirai H, Hirase H, Tsuboi T, Kitaguchi, T.
    Red fluorescent protein-based cAMP indicator applicable to optogenetics and in vivo imaging.
    Scientific Reports (2017) 7:7351 DOI: 10.1038/s41598-017-07820-6

  • Nakai N, Nagano M, Saitow F, Watanabe Y, Kawamura Y, Kawamoto A, Tamada K, Mizuma H, Onoe H, Watanabe Y, Monai M, Hirase H, Nakatani J, Inagaki H, Kawada T, Miyazaki T, Watanabe M, Sato Y, Okabe S, Kitamura K, Kano M, Hashimoto K, Suzuki H, Takumi T.
    Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice.
    Science Advances (2017) 3(6):e1603001 DOI: 10.1126/sciadv.1603001

  • Masamoto K, Hirase H, Yamada K, Kanno I.
    Neurovascular coupling - What next?
    Progress in Brain Research. (2016) 225:269-272. DOI: 10.1016/bs.pbr.2016.03.007

  • Aida T, Yoshida J, Nomura M, Tanimura A, Iino Y, Soma M, Bai N, Ito Y, Cui W, Aizawa H, Yanagisawa M, Nagai T, Takata N, Tanaka KF, Takayanagi R, Kano M, Götz M, Hirase H, Tanaka K.
    Astroglial Glutamate Transporter Deficiency Increases Synaptic Excitability and Leads to Pathological Repetitive Behaviors in Mice.
    Neuropsychopharmacology (2015) 40:1569-1579. DOI: 10.1038/npp.2015.26
  • Hashimoto M, Hata A, Miyata T, Hirase H.
    Programmable wireless light-emitting diode stimulator for chronic stimulation of optogenetic molecules in freely moving mice.
    Neurophotonics (2014) 1:011002. DOI: 10.1117/1.NPh.1.1.011002
  • Molter C, O'Neill J, Yamaguchi Y, Hirase H, Leinekugel X.
    Rhythmic modulation of theta oscillations supports encoding of spatial and behavioral information in the rat hippocampus.
    Neuron. (2012) 75(5):889-903. DOI: 10.1016/j.neuron.2012.06.036
  • Miyazaki T, Takase K, Nakajima W, Tada H, Ohya D, Sano A, Goto T, Hirase H, Malinow R, Takanashi T.
    Disrupted cortical function underlies behavior dysfunction due to social isolation.
    J Clin Invest. (2012) 122(7):2690-701. DOI: 10.1172/JCI63060
  • Kaneko M, Yamaguchi K, Eiraku M, Takata N, Kiyohara Y, Mishina M, Hirase H, Hashikawa T, Kengaku M.
    Remodeling of monoplanar Purkinje cell dendrites during cerebellar circuit formation.
    PLoS One. (2011) 6(5):e20108. DOI: 10.1371/journal.pone.0020108
  • Shinoda Y, Sadataka T, Nakao K, Katoh-Semba R, Kinameri E, Furuya A, Yanagawa Y, Hirase H, Furuichi T.
    Calcium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GABAergic interneuron network.
    Proc Natl Acad Sci U S A. (2011) 108(1):373-8. DOI: 10.1073/pnas.1012220108
  • Shinohara Y, Hosoya A, Yamasaki N, Ahmed H, Hattori S, Eguchi M, Yamaguchi S, Miyakawa T, Hirase H, Shigemoto R.
    Right-hemispheric dominance of spatial memory in split-brain mice.
    Hippocampus (2012) 22(2):117-121. DOI: 10.1002/hipo.20886
  • Shinohara Y, Hirase H, Watanabe M, Itakura M, Takahashi M, Shigemoto R.
    Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors.
    Proc Natl Acad Sci U S A. (2008) 105(49):19498-503. DOI: 10.1073/pnas.0807461105
  • Japanese publications/popular writings

  • 神経科学と計算機科学の融合 - RIKEN BSI News No. 40
  • Complete list of Dr. Hirase's Japanese publications